Alessandro Sette

Alessandro Sette is an Italian immunologist. He is a professor at La Jolla Institute for Immunology (LJI). He is an adjunct professor at the University of California, San Diego. Sette studies the specific epitopes that the immune system recognizes in cancer, autoimmunity, allergy, and infectious diseases.[1]

In 1988, Sette moved to San Diego to conduct research at San Diego biotech Cytel. He then co-founded Epimmune. In 2003, Sette joined the faculty of LJI.[2]

Sette co-leads the Immune Epitope Database (IEDB), an online database that catalogues epitopes involved in immune system recognition of allergens, infectious diseases, autoantigens, and transplanted tissue in humans and various species.[3]

In 2020, Sette published the first study of SARS-CoV-2 epitopes targeted by the human immune system.[4] He has co-led research into CD8+ and CD4+ T cell responses in COVID-19 patients[5] and studied CD8+ T cell cross-reactivity to SARS-CoV-2 epitopes and other coronaviruses.[6]

References
  1. "» Sette Lab". www.lji.org. Retrieved January 5, 2021.
  2. Sette, Alessandro (March 28, 2017). "Portrait of an optimist". Human Vaccines & Immunotherapeutics. 13 (6): 1210–1212. doi:10.1080/21645515.2017.1312175. ISSN 2164-5515. PMC 5489282. PMID 28350507.
  3. Fleri, Ward; Paul, Sinu; Dhanda, Sandeep Kumar; Mahajan, Swapnil; Xu, Xiaojun; Peters, Bjoern; Sette, Alessandro (2017). "The Immune Epitope Database and Analysis Resource in Epitope Discovery and Synthetic Vaccine Design". Frontiers in Immunology. 8: 278. doi:10.3389/fimmu.2017.00278. ISSN 1664-3224. PMC 5348633. PMID 28352270.
  4. Grifoni, Alba; Weiskopf, Daniela; Ramirez, Sydney I.; Mateus, Jose; Dan, Jennifer M.; Moderbacher, Carolyn Rydyznski; Rawlings, Stephen A.; Sutherland, Aaron; Premkumar, Lakshmanane; Jadi, Ramesh S.; Marrama, Daniel (June 25, 2020). "Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals". Cell. 181 (7): 1489–1501.e15. doi:10.1016/j.cell.2020.05.015. ISSN 0092-8674. PMC 7237901. PMID 32473127.
  5. Moderbacher, Carolyn Rydyznski; Ramirez, Sydney I.; Dan, Jennifer M.; Grifoni, Alba; Hastie, Kathryn M.; Weiskopf, Daniela; Belanger, Simon; Abbott, Robert K.; Kim, Christina; Choi, Jinyong; Kato, Yu (November 12, 2020). "Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity". Cell. 183 (4): 996–1012.e19. doi:10.1016/j.cell.2020.09.038. ISSN 0092-8674. PMC 7494270. PMID 33010815.
  6. Mateus, Jose; Grifoni, Alba; Tarke, Alison; Sidney, John; Ramirez, Sydney I.; Dan, Jennifer M.; Burger, Zoe C.; Rawlings, Stephen A.; Smith, Davey M.; Phillips, Elizabeth; Mallal, Simon (October 2, 2020). "Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans". Science. 370 (6512): 89–94. Bibcode:2020Sci...370...89M. doi:10.1126/science.abd3871. ISSN 0036-8075. PMC 7574914. PMID 32753554.


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