CKLF like MARVEL transmembrane domain containing 7

CKLF like MARVEL transmembrane domain containing 7 is a protein that in humans is encoded by the CMTM7 gene. [4]

CMTM7
Identifiers
AliasesCMTM7, CKLFSF7, CKLF like MARVEL transmembrane domain containing 7
External IDsOMIM: 607890 MGI: 2447166 HomoloGene: 15882 GeneCards: CMTM7
Orthologs
SpeciesHumanMouse
Entrez

112616

102545

Ensembl

ENSG00000153551

ENSMUSG00000032436

UniProt

Q96FZ5

Q9ESD6

RefSeq (mRNA)

NM_138410
NM_181472

NM_001252479
NM_133978

RefSeq (protein)

NP_612419
NP_852137

NP_001239408
NP_598739

Location (UCSC)Chr 3: 32.39 – 32.48 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor that regulates G1/S transition in the cell cycle, and epidermal growth factor receptor/protein kinase B signaling during tumor pathogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms.

References
  1. GRCh38: Ensembl release 89: ENSG00000153551 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Entrez Gene: CKLF like MARVEL transmembrane domain containing 7". Retrieved 2016-03-09.

Further reading
  • Han W, Ding P, Xu M, Wang L, Rui M, Shi S, Liu Y, Zheng Y, Chen Y, Yang T, Ma D (2003). "Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation". Genomics. 81 (6): 609–17. doi:10.1016/s0888-7543(03)00095-8. PMID 12782130.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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