Corosolic acid


Corosolic acid is a pentacyclic triterpene acid found in Lagerstroemia speciosa. It is similar in structure to ursolic acid, differing only in the fact that it has a 2-alpha-hydroxy attachment.[1]

Corosolic acid
Names
Preferred IUPAC name
(1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,11-Dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylic acid
Other names
Glucosol; Corsolic acid; Colosic acid; 2α-Hydroxyursolic acid
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.125.730
UNII
  • InChI=1S/C30H48O4/c1-17-10-13-30(25(33)34)15-14-28(6)19(23(30)18(17)2)8-9-22-27(5)16-20(31)24(32)26(3,4)21(27)11-12-29(22,28)7/h8,17-18,20-24,31-32H,9-16H2,1-7H3,(H,33,34)/t17-,18+,20-,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
    Key: HFGSQOYIOKBQOW-ZSDYHTTISA-N
  • InChI=1/C30H48O4/c1-17-10-13-30(25(33)34)15-14-28(6)19(23(30)18(17)2)8-9-22-27(5)16-20(31)24(32)26(3,4)21(27)11-12-29(22,28)7/h8,17-18,20-24,31-32H,9-16H2,1-7H3,(H,33,34)/t17-,18+,20-,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
    Key: HFGSQOYIOKBQOW-ZSDYHTTIBC
  • O=C(O)[C@@]54[C@H](/C3=C/C[C@H]1[C@](CC[C@@H]2[C@]1(C)C[C@@H](O)[C@H](O)C2(C)C)(C)[C@]3(C)CC4)[C@@H](C)[C@H](C)CC5
Properties
C30H48O4
Molar mass 472.710 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Axit corosolic giúp giảm nhanh glucose máu, tăng độ nhạy của insulin. Đồng thời tăng khả năng hấp thu glucose và ức chế enzyme alpha-glucosidase. Là enzyme giúp tiêu hóa carbohydrate, có tác dụng tương tự insulin.[2]

ursolic acid

References
  1. "Asiatic Acid, Corosolic Acid, and Maslinic Acid Interfere with Intracellular Trafficking and N-Linked Glycosylation of Intercellular Adhesion Molecule-1". doi:10.1248/bpb.b18-00276. Cite journal requires |journal= (help)
  2. Acid, corosolic. "Chuyên trang nghiên cứu về các hoạt chất trong điều trị bệnh tiểu đường". Chữa tiểu đường bằng thảo dược.


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