Francis O'Brien
Francis or Fran O'Brien may refer to:
- Francis O'Brien (Irish politician) (born 1943), Irish Fianna Fáil politician
- Francis O'Brien (cricketer) (1911–1991), New Zealand cricketer
- Francis O'Brien (Canadian politician) (born 1927), Canadian politician and farmer
- Fran O'Brien (American football) (1936–1999), American National Football League player
- Fran O'Brien (footballer) (born 1955), Irish footballer
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