Hexadecanal

Hexadecanal
Names
	IUPAC name hexadecanal
	Other names Hexadecanal; AI3-24252; EINECS 211-111-0; UNII-WQD27655QE
Identifiers
CAS Number	629-80-1;
3D model (JSmol)	Interactive image;
Beilstein Reference	1772756
ChEBI	CHEBI:17600;
ChEMBL	ChEMBL1235338;
ChemSpider	959;
DrugBank	DB03381;
ECHA InfoCard	100.010.102
EC Number	211-111-0;
Gmelin Reference	722456
IUPHAR/BPS	6627;
KEGG	C00517;
PubChem CID	984;
UNII	WQD27655QE;
CompTox Dashboard (EPA)	DTXSID5042039 ;
	InChI InChI=1S/C16H32O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17/h16H,2-15H2,1H3 Key: NIOYUNMRJMEDGI-UHFFFAOYSA-N;
	SMILES CCCCCCCCCCCCCCCC=O;
Properties
Chemical formula	C16H32O
Molar mass	240.428 g/mol
Hazards
	GHS labelling:
Pictograms
Signal word	Warning
Hazard statements	H315, H319, H335
Precautionary statements	P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

Hexadecanal is an organic compound with the chemical formula C₁₆H₃₂O.

In biology

Hexadecanal is found in human skin, saliva, and feces. It has a calming effect on mice.[1]

In 2021, inhalation of hexadecanal was found to reduce aggression in men but to trigger aggression in women.[2] Hexadecanal is one of the most abundant substances emitted by human babies from their heads, which may be an evolutionary survival mechanism to induce mothers to defend the baby and fathers to not attack it. But it is not yet known whether the amount of hexadecanal emitted by humans is sufficient to affect other humans.[3]

References

Klein, Bettina; Bautze, Verena; Maier, Anna-Maria; Deussing, Jan; Breer, Heinz; Strotmann, Jörg (2015). "Activation of the mouse odorant receptor 37 subsystem coincides with a reduction of novel environment-induced activity within the paraventricular nucleus of the hypothalamus". European Journal of Neuroscience. 41 (6): 793–801. doi:10.1111/ejn.12838. PMID 25619114. S2CID 39197364.
Mishor, Eva; Amir, Daniel; Weiss, Tali; Honigstein, Danielle; Weissbrod, Aharon; Livne, Ethan; Gorodisky, Lior; Karagach, Shiri; Ravia, Aharon; Snitz, Kobi; Karawani, Diyala (2021-11-19). "Sniffing the human body volatile hexadecanal blocks aggression in men but triggers aggression in women". Science Advances. 7 (47): eabg1530. doi:10.1126/sciadv.abg1530. ISSN 2375-2548. PMID 34797713. S2CID 244428241.
Underwood, Emily (2021-11-19). "Chemical emitted by babies could make men more docile, women more aggressive". Science. doi:10.1126/science.acx9685. S2CID 244449121.

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[1] Klein, Bettina; Bautze, Verena; Maier, Anna-Maria; Deussing, Jan; Breer, Heinz; Strotmann, Jörg (2015). "Activation of the mouse odorant receptor 37 subsystem coincides with a reduction of novel environment-induced activity within the paraventricular nucleus of the hypothalamus". European Journal of Neuroscience. 41 (6): 793–801. doi:10.1111/ejn.12838. PMID 25619114. S2CID 39197364.

[2] Mishor, Eva; Amir, Daniel; Weiss, Tali; Honigstein, Danielle; Weissbrod, Aharon; Livne, Ethan; Gorodisky, Lior; Karagach, Shiri; Ravia, Aharon; Snitz, Kobi; Karawani, Diyala (2021-11-19). "Sniffing the human body volatile hexadecanal blocks aggression in men but triggers aggression in women". Science Advances. 7 (47): eabg1530. doi:10.1126/sciadv.abg1530. ISSN 2375-2548. PMID 34797713. S2CID 244428241.

[3] Underwood, Emily (2021-11-19). "Chemical emitted by babies could make men more docile, women more aggressive". Science. doi:10.1126/science.acx9685. S2CID 244449121.