Integra LifeSciences

Integra LifeSciences is a global medical device manufacturing company headquartered in Princeton, New Jersey.[1][2] Founded in 1989, the company manufactures products for skin regeneration, neurosurgery, reconstructive and general surgery.[1] Integra artificial skin became the first commercially reproducible skin tissue used to treat severe burns and other skin wounds.[3] [4]

History

Integra LifeSciences was founded by Richard Caruso in 1989 after Caruso licensed Integra artificial skin technology from Harvard-MIT and acquired Colla-tec, a subsidiary of Marion Laboratories.[1][5] The company became publicly traded under the NASDAQ ticker name IART.[5]

In 1996, Integra artificial skin was approved by the U.S. Food and Drug Administration.[6] The artificial skin, manufactured and patented as Integra, is now used on patients with extensive burns.[3] In 1999, the FDA approved Integra LifeSciences’ DuraGen, an absorbable implant used in neurosurgical and spinal procedures.[7]

In 2001, the company received FDA approval for Licox, a brain tissue oxygen and temperature monitor.[8][9] Licox is used to treat patients in critical care, including those suffering from traumatic brain injuries.[8]

In 2002 the FDA approved the use of Integra Dermal Regeneration Template for reconstructive surgery of burn scars.[10] In 2016, IDRT received premarket approval from the FDA for the treatment of diabetic foot ulcers.[11]

Integra artificial skin

In 1969, John F. Burke, a surgeon and Harvard Medical School professor, and Ioannis V. Yannas, a mechanical engineering professor of fibers and polymers at MIT, began working on a new form of artificial skin.[3] They created the first commercially reproducible artificial skin, later patented and manufactured as Integra.[3]

Integra is used to treat patients with severe burns.[3][4][6] Integra is also used in plastic surgery, reconstructive surgery, and to treat some forms of cancer and other skin wounds.[4][12][13][14]

References
  1. Trenton, Joyce J. Persico | For The Times of (2011-09-30). "Integra upgrades Plainsboro office for skin regeneration market". nj. Retrieved 2021-10-12.
  2. "Integra LifeSciences Celebrates New Global Headquarters". New Jersey Business Magazine. Retrieved 2021-10-12.
  3. Vitello, Paul (2011-11-05). "Dr. John F. Burke, Dies at 89; Created Synthetic Skin". The New York Times. ISSN 0362-4331. Retrieved 2021-10-08.
  4. "New healing, hope for burn victims | The Seattle Times". archive.seattletimes.com. Retrieved 2021-10-08.
  5. Crosby, John C. (2019-06-13). Built to Help Each Other: Mentoring in the Life of Richard Caruso: An Uncommon Man. Radius Book Group. ISBN 978-1-63576-708-7.
  6. Schaffer, Amanda (2006-05-02). "Cadaver Skin Fills the Gap in Burn Cases". The New York Times. ISSN 0362-4331. Retrieved 2021-10-14.
  7. "Integra Lifesciences Cleared to Market New Dural Graft Matrix". www.meddeviceonline.com. Retrieved 2021-10-14.
  8. Stewart, Campbell (December 1, 2008). "THE NEW LICOX COMBINED BRAIN TISSUE OXYGEN AND BRAIN TEMPERATURE MONITOR: ASSESSMENT OF IN VITRO ACCURACY AND CLINICAL EXPERIENCE IN SEVERE TRAUMATIC BRAIN INJURY". Neurosurgery: The Register of the Neurosurgical Meme. 63: 1159–1165 – via Oxford Academic.
  9. Layon, Joseph A.; Gabrielli, Andrea; Friedman, William A. (2013). Textbook of Neurointensive Care. Springer. p. 135. ISBN 978-1-4471-5225-5.
  10. "FDA approves Integra Omnigraft Dermal Regeneration Matrix to treat diabetic foot ulcers". FDA. 2018-11-03. Retrieved 2021-10-14.
  11. "Premarket Approval (PMA)". www.accessdata.fda.gov. Retrieved 2021-10-14.
  12. Thinda, Sumeer; Wright, Harry V.; Mawn, Louise A. (February 2012). "Integra Bilayer Matrix Wound Dressing Closure of Large Periorbital Traumatic Wound". Surgal Technique | Surgeon's corner – via JAMA Network.
  13. Chang, Daniel K.; Louis, Matthew R.; Gimenez, Alejandro; Reece, Edward M. (August 2, 2019). "The Basics of Integra Dermal Regeneration Template and its Expanding Clinical Applications". Seminars in Plastic Surgery – via NCBI.
  14. Chalmers, R L; Smock, E; Geh, J L C (March 23, 2010). "Experience of Integra(®) in cancer reconstructive surgery". PubMed – via National Library of Medicine.
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