Mammalian Genetics Unit

The Mammalian Genetics Unit is a genetics and genomics research institute in Oxfordshire.

Mammalian Genetics Unit
Abbreviation	MGU
Formation	1995
Type	Research institute
Legal status	Government agency
Purpose	Genetics research in the UK
Location	Oxfordshire, OX11 0RD
Coordinates	51°35′N 1°19′W
Region served	UK
Parent organization	Medical Research Council
Staff	c. 400 genetics scientists
Website	MGU

History

Earlier research on the same site at the Radiobiology Research Unit, which opened in 1954, in the 1950s was into cytogenetics, where Charles Edmund Ford and John Hamerton confirmed on 12 January 1956 the size of the human genome. In the early 1970s this unit led research into mutagenic effects of radiation on the human chromosome. In the mid-1980s, important early work was done in genomic imprinting.

From 2007, the site no longer carried work into the effects of radiation on genes (radiobiology).

MGU

The MGU is largely derived from the earlier Radiobiology Unit (RBU). In 2010, work at the unit discovered that overexpression of the FTO gene led to obesity.

Structure

The unit is in Oxfordshire.[1]

Function

The unit carries out work into genetics and genome engineering.

References

"Oxfordshire Apprenticeships". oxfordshireapprenticeships.co.uk. Retrieved 2017-09-19.

External links

Gene expression

Introduction
to genetics

Transcription

Types	Bacterial Archaeal Eukaryotic
Key elements	Transcription factor RNA polymerase Promoter
Post-transcription	Precursor mRNA (pre-mRNA / hnRNA) 5' capping Splicing Polyadenylation Histone acetylation and deacetylation

Translation

Types	Bacterial Archaeal Eukaryotic
Key elements	Ribosome Transfer RNA (tRNA) Ribosome-nascent chain complex (RNC) Post-translational modification

Regulation

Influential people

Omics
Genomics	Cognitive genomics Computational genomics Comparative genomics Functional genomics Genome project Human Genome Project Metagenomics Pangenomics Personal genomics Population genomics Social genomics Structural genomics
Bioinformatics	Biochip Cheminformatics Chemogenomics Connectomics Human Connectome Project Epigenomics Human Epigenome Project Glycomics Immunomics Lipidomics Metabolomics Microbiomics Nutrigenomics Paleopolyploidy Pharmacogenetics Pharmacogenomics Systems biology Toxicogenomics Transcriptomics
Structural biology	Proteomics Human proteome project Call-map proteomics Structure-based drug design Expression proteomics
Research tools	2-D electrophoresis Mass spectrometer Electrospray ionization Matrix-assisted laser desorption ionization Matrix-assisted laser desorption ionization-time of flight mass spectrometer Microfluidic-based tools Isotope affinity tags Chromosome conformation capture
Organizations	DNA Data Bank of Japan (JP) European Molecular Biology Laboratory (EU) National Institutes of Health (USA) Wellcome Sanger Institute (UK)
List Category

The District of the Vale of White Horse
Oxfordshire County Council elections District Council elections Wantage County Constituency Oxford West and Abingdon County Constituency
Towns	Abingdon-on-Thames Caldecott Faringdon Wantage Belmont
Large villages	Blewbury Cumnor Chilswell Cumnor Hill Dean Court Farmoor Swinford Drayton East Challow East Hendred Grove Harwell Kennington Kingston Bagpuize with Southmoor Kingston Bagpuize Southmoor Marcham Cothill Milton North Hinksey Botley Harcourt Hill Radley St. Helen Without Dry Sandford Shippon Shrivenham Stanford in the Vale Bow Steventon Sunningwell Bayworth Boars Hill Foxcombe Hill Sutton Courtenay Watchfield Wootton Boars Hill Henwood Lamborough Hill
Other civil parishes (component villages and hamlets)	Appleford-on-Thames Appleton-with-Eaton Appleton Eaton Ardington and Lockinge Ardington Ardington Wick East Lockinge West Lockinge West Ginge Ashbury Idstone Kingstone Winslow Baulking Besselsleigh Bourton Buckland Gainfield Buscot Charney Bassett Childrey Chilton Coleshill Compton Beauchamp Knighton Denchworth East Hanney Eaton Hastings Fernham Frilford Fyfield and Tubney Fyfield Tubney Netherton Garford Goosey Great Coxwell Hatford Little Hatford Hinton Waldrist Duxford Kingston Lisle Letcombe Bassett Letcombe Regis Little Coxwell Littleworth Longcot Longworth Lyford Pusey Shellingford South Hinksey Hinksey Hill Sparsholt Uffington Upton West Challow West Hanney West Hendred East Ginge Woolstone Wytham Seacourt
Former districts and boroughs	Municipal Borough of Abingdon Abingdon Rural District Faringdon Rural District Wantage Urban District Wantage Rural District
Former constituencies	Oxfordshire County Constituency Abingdon Borough Constituency Berkshire North or Abingdon County Constituency Abingdon County Constituency
List of Parliamentary constituencies in Oxfordshire List of places in Oxfordshire List of civil parishes in Oxfordshire

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