Manny

• Manny Acosta (born 1981), Panamanian pitcher in the Mexican Baseball League
• Manny Acta (born 1969), former Major League Baseball player, manager and coach
• Manny Alexander (born 1971), Dominican former Major League Baseball player
• Manny Aparicio (born 1995), Canadian soccer player
• Manny Aragon (born 1947), former New Mexico State Senator, later convicted of conspiracy to defraud
• Manny Banuelos (born 1991), Mexican pitcher in Major League Baseball
• Emmanuel Burriss (born 1985), American Major League Baseball player
• Manny Charlton (born 1941), a founding member and lead guitarist of the Scottish hard rock band Nazareth
• Manny Corpas (born 1982), Panamanian pitcher in Major League Baseball and the Mexican Baseball League
• Manny Coto (fl. 1988-present), Cuban-American film and television writer, director and producer
• Manny Curtis (1911–1984), American songwriter born Emanuel Kurtz
• Manny Delcarmen (born 1982), American pitcher in the Mexican Baseball League
• Manny Diaz (disambiguation)
• Manny Elias (born 1953), Indian-born English drummer, original drummer of Tears for Fears
• Manny Fernandez (disambiguation)
• Manny Gonzalez (soccer) (born 1990), Colombian-American soccer player
• Manny Jacinto (born 1987), Filipino-born Canadian actor
• Manny Lawson (born 1984), American National Football League player
• Manny Lehman (computer scientist) (1925–2010), professor of computer science
• Manny Machado (born 1992), Dominican-American Major League Baseball player
• Manny Malhotra (born 1980), Canadian National Hockey League player
• Manny Marroquin (born 1971), Guatemalan-born American mixing engineer
• Manny Martínez (baseball) (born 1970), former Major League Baseball player
• Manny Mota (born 1938), Dominican retired Major League Baseball player
• Manny Muscat (born 1984), Australian-born Maltese footballer
• Manny Oquendo (1931–2009), American percussionist
• Manny Pacquiao (born 1978), Filipino former boxer and politician
• Manny Paner (born 1949), retired Philippine Basketball Association player, member of the PBA Hall of Fame
• Manny Pangilinan (born 1946), Filipino businessman
• Manny Parra (born 1982), American Major League Baseball pitcher
• Manny Pérez (born 1969), Dominican-American actor
• Manny Ramirez (born 1972), Dominican-American retired Major League Baseball player
• Manny Ramirez (American football) (born 1983), American National Football League player
• Emanuel (Manny) Rosenfeld (died 1959), co-founder and CEO of the Pep Boys automotive aftermarket chain
• Manny Sanguillén (born 1944), Panamanian retired Major League Baseball player
• Manny Trillo (born 1950), Venezuelan former Major League Baseball player
• Manny Victorino (born 1959), retired Philippine Basketball Association player
• Manny Villar, Jr. (born 1949), Filipino businessman and politician
• Manny Wilkins (born 1995), American football player

• Manny Armstrong, a Ben 10 character
• Manny Bianco, in the sitcom Black Books
• Manny Calavera, the main character of Lucasarts video game Grim Fandango
• Manny Heffley, one of the main characters in the Diary of a Wimpy Kid book and film series
• Manuel "Manny" O'Kelly-Davis, in The Moon Is a Harsh Mistress, a science fiction novel by Robert Heinlein
• Manny Rivera, the title character of El Tigre: The Adventures of Manny Rivera
• Manny Santos, in Degrassi: The Next Generation
• Manny Spamboni, a character from TV series, The Electric Company
• Manny (Ice Age), a woolly mammoth in the Ice Age film series
• Manny, a praying mantis in the 1998 Disney/Pixar animated film A Bug's Life
• Manny, the title character of Handy Manny, a children's television series
• Manny Delgado, a character in the sitcom Modern Family.
• Manny Pardo, a police detective from Hotline Miami 2: Wrong Number.
• Manny Alvarez, a character in The Last of Us: Part II played by Alejandro Edda
• Manny, corrupt police officer in Scarface.

＊ Manny Quinlan, friend and police contact of Harry Orwell, played by Henry Darrow in the TV series "Harry O", starring David Janssen.

• Mannie, a given name