List of human spaceflights, 2021–present

This is a detailed list of human spaceflights from 2021 to present.

• Green indicates a suborbital flight (including flights that failed to attain intended orbit).

#	Crew	Launch spacecraft	Habitation	Return spacecraft	Brief mission summary
329	Oleg Novitsky	9 April 2021 Soyuz MS-18	ISS (crew 64/65)	17 October 2021 Soyuz MS-18	ISS crew rotation.
	Pyotr Dubrov Mark T. Vande Hei		ISS (crew 64/65/66)	in orbit
330	Shane Kimbrough K. Megan McArthur Akihiko Hoshide Thomas Pesquet	23 April 2021 SpaceX Crew-2, Endurance	ISS (crew 65/66)	9 November 2021 SpaceX Crew-2, Endurance	ISS crew rotation.
—	Frederick W. Sturckow Dave Mackay	22 May 2021 Unity 21			First human spaceflight from the State of New Mexico. Reached an altitude of 89.24 km (55.45 mi), crossing the U.S. definition of space, but not the FAI's definition.
331	Nie Haisheng Liu Boming Tang Hongbo	17 June 2021 Shenzhou 12	TSS	17 September 2021 Shenzhou 12	First crew to Tiangong Space Station.
—	David Mackay Michael Masucci Beth Moses Richard Branson Colin Bennett Sirisha Bandla	11 July 2021 Unity 22			Reached an altitude of 86 km (53 mi), crossing the U.S. definition of space.
332	Jeff Bezos Mark Bezos Wally Funk Oliver Daemen	20 July 2021 NS 16			Reached an altitude of 107 km (66 mi), crossing the FAI definition of space.
333	Jared Isaacman Sian Proctor Hayley Arceneaux Christopher Sembroski	16 September 2021 Inspiration4, Resilience		18 September 2021 Inspiration4, Resilience
334	Klim Shipenko Yulia Peresild	5 October 2021 Soyuz MS-19	ISS (Vyzov)	17 October 2021 Soyuz MS-18	ISS crew rotation.
	Anton Shkaplerov		ISS (crew 65/66)	in orbit
335	Audrey Powers Chris Boshuizen Glen de Vries William Shatner	13 October 2021 NS 18			Reached an altitude of 107 km (66 mi), crossing the FAI definition of space.
336	Zhai Zhigang Wang Yaping Ye Guangfu	15 October 2021 Shenzhou 13	TSS	in orbit	Second crew to Tiangong Space Station.
337	Raja Chari Thomas Marshburn Kayla Barron Matthias Maurer	11 November 2021 SpaceX Crew-3, Endurance	ISS (crew 66/67)	in orbit	ISS crew rotation.
338	Alexander Misurkin Yusaku Maezawa Yozo Hirano	8 December 2021, Soyuz MS-20	ISS	in orbit
339	Laura Shepard Churchley Michael Strahan Dylan Taylor Evan Dick Lane Bess Cameron Bess	11 December 2021 NS 19			Reached an altitude of greater than 100 km (62 mi), crossing the FAI definition of space.