UGT2B10

UGT2B10
Identifiers
Aliases	UGT2B10, UDPGT2B10, UDP glucuronosyltransferase family 2 member B10
External IDs	OMIM: 600070 MGI: 2140962 HomoloGene: 117389 GeneCards: UGT2B10
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	68,832,023 bp[1]
RNA expression pattern
	Top expressed in
	liver; ; Right lobe of liver; ; kidney; ; pancreas; ; spleen; ; lung; ; multicellular organism; ; gallbladder; ; heart;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glycosyltransferase activity; transferase activity; hexosyltransferase activity; glucuronosyltransferase activity; UDP-glycosyltransferase activity;
Cellular component	integral component of membrane; organelle membrane; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; endoplasmic reticulum; membrane;
Biological process	metabolism; lipid metabolism;
	Sources:Amigo / QuickGO
Orthologs
	7365
	100727
	ENSG00000275190; ENSG00000109181
	ENSMUSG00000029260
	P36537
	n/a
	NM_001290091; NM_001075; NM_001144767
	NM_153598
	NP_001066; NP_001138239; NP_001277020
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

UDP-glucuronosyltransferase 2B10 is an enzyme that in humans is encoded by the UGT2B10 gene.[4][5] It is responsible for glucuronidation of nicotine and cotinine.[6][7]

References

ENSG00000109181 GRCh38: Ensembl release 89: ENSG00000275190, ENSG00000109181 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Jin CJ, Miners JO, Lillywhite KJ, Mackenzie PI (July 1993). "cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily". Biochemical and Biophysical Research Communications. 194 (1): 496–503. doi:10.1006/bbrc.1993.1847. PMID 8333863.
"Entrez Gene: UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10".
Chen G, Giambrone NE, Dluzen DF, Muscat JE, Berg A, Gallagher CJ, Lazarus P (October 2010). "Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms". Cancer Research. 70 (19): 7543–52. doi:10.1158/0008-5472.CAN-09-4582. PMC 2998997. PMID 20876810.
Wassenaar CA, Conti DV, Das S, Chen P, Cook EH, Ratain MJ, et al. (January 2015). "UGT1A and UGT2B genetic variation alters nicotine and nitrosamine glucuronidation in european and african american smokers". Cancer Epidemiology, Biomarkers & Prevention. 24 (1): 94–104. doi:10.1158/1055-9965.EPI-14-0804. PMC 4294984. PMID 25277794.

Chen G, Dellinger RW, Gallagher CJ, Sun D, Lazarus P (March 2008). "Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines". Pharmacogenetics and Genomics. 18 (3): 181–91. doi:10.1097/FPC.0b013e3282f4dbdd. PMID 18300939. S2CID 19295110.
Chen G, Blevins-Primeau AS, Dellinger RW, Muscat JE, Lazarus P (October 2007). "Glucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism". Cancer Research. 67 (19): 9024–9. doi:10.1158/0008-5472.CAN-07-2245. PMID 17909004.
Kaivosaari S, Toivonen P, Hesse LM, Koskinen M, Court MH, Finel M (September 2007). "Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10". Molecular Pharmacology. 72 (3): 761–8. doi:10.1124/mol.107.037093. PMID 17576790. S2CID 6062166.
Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". Journal of Proteome Research. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Strassburg CP, Kneip S, Topp J, Obermayer-Straub P, Barut A, Tukey RH, Manns MP (November 2000). "Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine". The Journal of Biological Chemistry. 275 (46): 36164–71. doi:10.1074/jbc.M002180200. PMID 10748067.
Strassburg CP, Strassburg A, Nguyen N, Li Q, Manns MP, Tukey RH (March 1999). "Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus". The Biochemical Journal. 338 ( Pt 2) (2): 489–98. doi:10.1042/0264-6021:3380489. PMC 1220077. PMID 10024527.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

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[refGRCh38Ensembl-1] ENSG00000109181 GRCh38: Ensembl release 89: ENSG00000275190, ENSG00000109181 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8333863-4] Jin CJ, Miners JO, Lillywhite KJ, Mackenzie PI (July 1993). "cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily". Biochemical and Biophysical Research Communications. 194 (1): 496–503. doi:10.1006/bbrc.1993.1847. PMID 8333863.

[entrez-5] "Entrez Gene: UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10".

[pmid20876810-6] Chen G, Giambrone NE, Dluzen DF, Muscat JE, Berg A, Gallagher CJ, Lazarus P (October 2010). "Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms". Cancer Research. 70 (19): 7543–52. doi:10.1158/0008-5472.CAN-09-4582. PMC 2998997. PMID 20876810.

[pmid25277794-7] Wassenaar CA, Conti DV, Das S, Chen P, Cook EH, Ratain MJ, et al. (January 2015). "UGT1A and UGT2B genetic variation alters nicotine and nitrosamine glucuronidation in european and african american smokers". Cancer Epidemiology, Biomarkers & Prevention. 24 (1): 94–104. doi:10.1158/1055-9965.EPI-14-0804. PMC 4294984. PMID 25277794.

UGT2B10

See Also

References

Further reading